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The Main Street Hotel is located on historic Main Street in Yazoo City, Mississippi.  We are truly the place to stay in Yazoo City if you are looking for accommodations that are both fun and unique! 

Situated on the second floor, above the historic buildings of Main Street, each hotel suite features a delightful ambiance with balcony access and street view, (note: inner rooms do not have windows), Flat screen televisions, refrigerator, microwave, and other home away from home amenities are available upon request.

Each room at the Main Street Hotel is uniquely decorated with fine linens, antique furniture, bathrooms with claw-foot tubs and showers, and more. All rooms are non-smoking and we do not allow pets.       

The balcony is accessible from all rooms through the hallway.

Hotel in Yazoo City, MS

The Main Street Hotel is proud to feature our very own reception hall.
"The No Smoking Smoke House" offers an unparalleled Delta experience.

Book our venue for wedding receptions, reunions, business meetings and parties.

Call us for help with information about booking your next event. 

Facebook Page of Hotel in Yazoo City, MS.

Save money by booking direct

 662-751-8886 or find us on 

$10 Off For AARP & AAA Members

For things to do in Yazoo City, visit our own Convention and Visitors Bureau

We even have our own AMTRAK station

just 3 blocks away

Book Direct to save!
For Reservations Call:

Or visit our Mayor's web page for

more information on Yazoo City

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